Increased Radiosensitivity of a Subpopulation of T-Lymphocyte Progenitors From Patients With Fanconi’s Anemia
نویسندگان
چکیده
In vitro radiation survival of peripheral blood T lymphocytes was studied in 1 5 clinically normal adults and 4 patients with Fanconi’s anemia. Tritiated thymidine incorporation in a whole blood lymphocyte stimulation test (1ST) and a newly developed whole blood T-lymphocyte colony assay were used to measure lymphocyte blastogenesis and colony formation in response to phytohemagglutinin (PHA) or concanavalin-A (Con-A) stimulation. Lymphocyte colony formation was found to be consistently more sensitive than the LST for detection of low-level radiation effects using both normal cells and lymphocytes from Fanconi’s anemia patients. Lymphocytes from patients with Fanconi’s anemia were significantly more
منابع مشابه
Increased radiosensitivity of a subpopulation ot T-lymphocyte progenitors from patients with Fanconi's anemia.
In vitro radiation survival of peripheral blood T lymphocytes was studied in 15 clinically normal adults and 4 patients with Fanconi's anemia. Tritiated thymidine incorporation in a whole blood lymphocyte stimulation test (LST) and a newly developed whole blood T-lymphocyte colony assay were used to measure lymphocyte blastogenesis and colony formation in response to phytohemagglutinin (PHA) or...
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